Emerging applications of label-free optical biosensors
Innovative technical solutions to realize optical biosensors with improved performance are continuously proposed. Progress in material fabrication enables developing novel substrates with enhanced optical responses. At the same time, the increased spectrum of …
Optofluidic bioanalysis: fundamentals and applications
Over the past decade, optofluidics has established itself as a new and dynamic research field for exciting developments at the interface of photonics, microfluidics, and the life sciences. The strong desire for developing miniaturized bioanalytic devices and …
Comparison between Vernier-cascade and MZI as transducer for biosensing with on-chip spectral filter
The Mach-Zehnder interferometer (MZI) and the Vernier-cascade are highly responsive photonic sensors with large design freedom. They are therefore very suitable for interrogation through a broadband source and an on-chip spectral filter, a sensing scheme that …
Surface chemistry and morphology in single particle optical imaging
Biological nanoparticles such as viruses and exosomes are important biomarkers for a range of medical conditions, from infectious diseases to cancer. Biological sensors that detect whole viruses and exosomes with high specificity, yet without additional …
Biosensing with optical fiber gratings
Optical fiber gratings (OFGs), especially long-period gratings (LPGs) and etched or tilted fiber Bragg gratings (FBGs), are playing an increasing role in the chemical and biochemical sensing based on the measurement of a surface refractive index (RI) change …
Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care
Point-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, self-contained, and can be used anywhere – from modern clinics to remote and low resource …
Comparison of supervised machine learning algorithms for waterborne pathogen detection using mobile phone fluorescence microscopy
is a waterborne parasite that affects millions of people every year worldwide, causing a diarrheal illness known as giardiasis. Timely detection of the presence of the cysts of this parasite in drinking water is important to prevent the spread of the disease, …
Introduction to the special issue of optical biosensors
Prior to the development of analytical devices to assist medical professionals, clinical diagnosis relied mostly on medical history and physical examination. Since many diseases could exhibit similar symptoms, doctors have always sought complementary …